Expiration date: 01/2027
Contraindications
Hypoglycemia, hypersensitivity to insulin or to one of the components of the drug.
The safety and efficacy of Humalog Mix 50 in patients under 18 years of age has not been studied.
Use during pregnancy and lactation
There have been no sufficient and well-controlled studies in pregnant women. Patients suffering from diabetes mellitus are advised to inform the doctor about the pregnancy that has occurred or is planned. During pregnancy, it is especially important to monitor the condition of patients receiving insulin therapy. The need for insulin usually decreases during the 1st trimester and increases during the second and third trimesters. During and immediately after childbirth, the need for insulin may decrease dramatically.
Patients with diabetes mellitus may need to adjust the dose of insulin, diet, or both during breastfeeding.
Side effects
Hypoglycemia is the most common side effect that occurs when all insulin preparations are administered, including Humalog Mix 50. Severe hypoglycemia can lead to loss of consciousness and, in exceptional cases, death.
Allergic reactions: patients may experience local allergic reactions in the form of redness, swelling or itching at the injection site. These minor reactions usually disappear within a few days or weeks. In some cases, these reactions may be caused by causes unrelated to insulin, such as skin irritation with a cleansing agent or improper injection.
Systemic allergic reactions caused by insulin occur less frequently, but are more serious. They can manifest as generalized itching, difficulty breathing, shortness of breath, decreased blood pressure, increased pulse rate, increased sweating. Severe cases of systemic allergic reactions can be life-threatening. In rare cases of severe allergy to Humalog Mix 50, immediate treatment is required. It may require a change of insulin, or desensitization.
With prolonged use, lipodystrophy may develop at the injection site.
Interaction
The hypoglycemic effect of Humalog Mix 50 is reduced when co-administered with the following drugs: oral contraceptives, glucocorticosteroids, iodine-containing thyroid hormones, danazol, beta2-adrenomimetics (e.g., ritodrine, salbutamol, terbutaline), thiazide diuretics, chlorprotixen, diazoxide, isoniazid, nicotinic acid, phenothiazine derivatives.
The hypoglycemic effect of Humalog Mix 50 is enhanced by: beta-blockers, ethanol and ethanol-containing drugs, anabolic steroids, fenfluramine, guanethidine, tetracyclines, oral hypoglycemic drugs, salicylates (for example, acetylsalicylic acid), sulfonamide antibiotics, some antidepressants (monoamine oxidase inhibitors), ACE inhibitors (captopril, enapril), octreotide, receptor antagonists Angiotensin II.
Beta-blockers, clonidine, reserpine can mask the symptoms of hypoglycemia.
The interaction of Humalog Mix 50 with other insulin preparations has not been studied.
Overdose
An overdose of insulin causes hypoglycemia, accompanied by the following symptoms: lethargy, excessive sweating, tachycardia, pallor of the skin, headache, trembling, vomiting, confusion. Under certain conditions, for example, with a long duration of the disease or with intensive control of diabetes mellitus, the symptoms-precursors of hypoglycemia may change.
Mild conditions of hypoglycemia can usually be stopped by ingestion of glucose or sugar. You may need to adjust your insulin dose, diet, or physical activity. Correction of moderate hypoglycemia can be carried out by intramuscular or subcutaneous administration of glucagon, followed by ingestion of carbohydrates. Severe hypoglycemia, accompanied by coma, seizures or neurological disorders, is relieved by intramuscular / subcutaneous administration of glucagon or intravenous administration of a concentrated dextrose (glucose) solution.
After restoring consciousness, the patient must be given food rich in carbohydrates in order to avoid the recurrence of hypoglycemia.
Further intake of carbohydrates and subsequent monitoring of the patient may be required, as a recurrence of hypoglycemia may occur.
